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As for NFS, NFS itself does not support any kind of access synchronization at all (!). Access synchronization on NFS is performed using an additional daemon software called rpc.lockd. So if you have a NFS server that has a functional rpc.lockd daemon and all NFS clients support the rpc.lockd protocol, then you can use NFS to share a message base between multiple computers. The bad news is that I have not seen a working rpc.lockd on either FreeBSD or Linux, and at least the NFS client for OS/2 (as probably all other Non-Unix NFS clients) does not support the rpc.lockd protocol. If you want rpc.lockd to work, you currently must use AIX or Digital Unix or maybe also some other commercial Unix. Not an option for the home user, I fear.
The essence is: You cannot use NFS to share a message base between multiple computers.